BioMachines Nanoscopy Lab

The Weiss lab is an interdisciplinary group in the Department of Engineering Physics at Polytechnique Montreal. We develop tools that have broad applications ranging from probing the physical properties of biomaterials to biomedical diagnostics.

Le labo Weiss est un groupe interdisciplinaire du Département de génie physique de Polytechnique Montréal. Nous développons des outils qui ont de larges applications allant de l'étude des propriétés physiques des biomatériaux au diagnostic biomédical.

An animation reading Weiss Lab in bioluminescent fluid.

A bioluminescent media flowing through a microfluidic channel (Thanks Omer!)

Coming soon

A guide to single-particle tracking. F Simon, LE Weiss, S van Teeffelen. Nature Reviews Methods Primers (Accepted, 2024).
- Experimental and analysis guide -

Detecting directed motion and confinement in single-particle trajectories using hidden variables. F Simon et al. BioRxiv (2024).
- Operates on single tracks or populations of tracks -
- Classifies motion type and performs statistical likelihood tests  -

Large-scale visualisation of α-synuclein oligomers in Parkinson's disease brain tissue. Andrews, Fu, & Toomey et al. BioRxiv (2024).
- Co-localization -
- High-throughput pipeline -

The nuclear basket regulates the distribution and mobility of nuclear pore complexes in budding yeast. Zsok et al.
- Biophysical insight into the nuclear pore complex and nuclear basket proteins -
- 3D particle trajectory simulation

Lab Fun

Lab BBQ, 2024

Lab Minigolf, 2024

Lab bowling, 2023

Innovation day, 2023

Bombardier handball, 2023

Power-outage foosball, 2023

Aligning a new setup, 2022

Custom sample incubator by Elham, 2022

Lab-practice event, 2021