The Weiss lab is an interdisciplinary group in the Department of Engineering Physics at Polytechnique Montreal. We develop tools that have broad applications ranging from probing the physical properties of biomaterials to biomedical diagnostics.
Le labo Weiss est un groupe interdisciplinaire du Département de génie physique de Polytechnique Montréal. Nous développons des outils qui ont de larges applications allant de l'étude des propriétés physiques des biomatériaux au diagnostic biomédical.
Patch deconvolution for Fourier light-field microscopy. B Fu et al. Biophysical Journal (2026).
doi.org/10.1101/2025.06.13.659385
- Fast 3D reconstruction -
Detecting directed motion and confinement in single-particle trajectories using hidden variables. F Simon et al. eLife (2026). doi.org/10.7554/eLife.99347.1
- Operates on single tracks or populations of tracks -
- Classifies motion type and performs statistical likelihood tests -
Analyzing single-molecule dynamics with both complex types of motion and complex transition kinetics: Benchmarking of ExaTrack. F. Simon et al. BioRxiv (2026).
doi.org/tbd
- Localization microscopy -
- Single-particle tracking -
α-Synuclein driven cell susceptibility in Parkinson's disease. J Breiter & JS Beckwith et al. BioRxiv (Submitted 2025).
doi.org/10.1101/2025.08.19.670819
- Localization microscopy -
Condition-dependent, amorphous protein agglomerates control cytoplasmic rheology. J Losa et al. BioRxiv (Under revision, 2025).
doi.org/10.1101/2025.06.17.660151
- Trajectory analysis -
Fast analytical method to integrate multivariate Gaussians over hidden variables. FC Simon, J Cardona, S Molesky, LE Weiss. HAL (Submitted 2025).
hal.science/hal-04692487v2
- Statistical analysis framework -
- Trajectory analysis -